Featuring some of the most famous Jewish artists in history, the display includes works by Marc Chagall, Chaim Soutine, Lazar Berson and Sonia Delaunay.
The School of Paris was the name given to an association of émigré artists working in the French capital in the early 20th century.
It included members of the Jewish community who had fled poverty and persecution in Russia to settle in Paris, where they had the freedom to pursue their artistic careers.
Highlights of the exhibition include Marc Chagall's Apocalypse en Lilas, Capriccio, a crucifixion scene he painted in response to horror stories about concentration camps that were being broadcast in the American press.
It is thought that it was these reports that forced the artist to finally come out of mourning for his late wife Bella – who had died suddenly the year before – as he felt compelled to begin work on the piece.
This is the first exhibition of major Jewish artists ever staged in Manchester, the city with the second largest Jewish population in the UK.